Genetic risk prediction in complex disease
نویسندگان
چکیده
منابع مشابه
Genetic risk prediction in complex disease
Attempting to classify patients into high or low risk for disease onset or outcomes is one of the cornerstones of epidemiology. For some (but by no means all) diseases, clinically usable risk prediction can be performed using classical risk factors such as body mass index, lipid levels, smoking status, family history and, under certain circumstances, genetics (e.g. BRCA1/2 in breast cancer). Th...
متن کاملPrediction of individual genetic risk of complex disease.
Most common diseases are caused by multiple genetic and environmental factors. In the last 2 years, genome-wide association studies (GWAS) have identified polymorphisms that are associated with risk to common disease, but the effect of any one risk allele is typically small. By combining information from many risk variants, will it be possible to predict accurately each individual person's gene...
متن کاملPrediction of genetic risk of complex diseases by supervised learning
The majority of important medical disorders (f.i. susceptibility to cancer, cardiovascular diseases, diabetes, Crohn’s disease) are said to be complex. This means that these diseases are influenced by multiple, often interacting environmental and genetic risk factors. The fact that individuals di↵er in terms of exposure to environmental as well as genetic factors explains the observed inter-ind...
متن کاملthe recurrence risk of genetic complex diseases
complex inherited diseases affected by an interaction between collective effects of the genotype at one or multiple loci either to increase or to lower susceptibility to disease, combined with a variety of environmental exposures that may trigger, accelerate, exacerbate, or protect against the disease process. the new aspects of genetic techniques have been opened for diagnosis and analysis of ...
متن کاملMultilocus genetic risk scores for coronary heart disease prediction.
OBJECTIVE Current guidelines do not support the use of genetic profiles in risk assessment of coronary heart disease (CHD). However, new single nucleotide polymorphisms associated with CHD and intermediate cardiovascular traits have recently been discovered. We aimed to compare several multilocus genetic risk score (MGRS) in terms of association with CHD and to evaluate clinical use. APPROACH...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2011
ISSN: 1460-2083,0964-6906
DOI: 10.1093/hmg/ddr378